Everything about ceesdekker.net

Halfway as a result of his occupation, Cees Dekker reinvented himself. After several years of hardcore physics, he shifted his concentrate to ‘nanobiology’ with the flip on the millennium. A term he coined himself, being a make any difference of truth.

Our group experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our primary interest lies in mobile division, chromatin construction, and spatial Handle.

[Laughs] ‘It had been unquestionably a great possibility! At the time, I was perfectly aware that it could go Improper and that I could come to be significantly less prosperous, but I just ignored that. Curiosity has usually been my strongest driving force. And luckily it all labored out.’

Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.

2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with ever study with the dynamics DNA supercoils and the discovery of supercoil hopping

Our analysis ranges in the biophysics of DNA to synthetic cells and beyond. Be sure to take a look down below within the spectrum of our present tasks.

We use nanofabricated microfluidic buildings to sample spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks which evaluate the elemental purpose of spatial confinement within the molecular and mobile stage. Our assignments incorporate the next:

Stream-pushed rotary motors including windmills and h2o wheels push functional processes in human Culture. While samples of such rotary motors also attribute prominently in mobile biology, their artificial construction on the nanoscale has remained hard. In this article we demonstrate flow-driven rotary motion of the self-arranged DNA nanostructure that may be docked on to a nanopore in a skinny good-state membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the good-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.

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There was one issue while — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these kinds of good conductors, which was alternatively disappointing. We thus broadened our see to try to locate much more promising molecules.

An built-in microfluidic platform for ceesdekker.net quantifying drug permeation across biomimetic vesicle membranes

‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and recognized about 5 hundred genes that are minimally essential for a working mobile. We wish to appear bottom-up: how can we move from a number of molecules to an entire biological program?

2008, to start with observation of protein-coated DNA translocation through nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; learned a big velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid

Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design in 2005. (nl)